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Sub-Category:

Immune-Mediated Glomerulopathies

Number of Conditions: 1

Membranoproliferative Glomerulonephritis (MPGN)

Specialty: Nephrology

Category: Glomerular Diseases

Sub-category: Immune-Mediated Glomerulopathies

Symptoms:
blood in the urine; foamy urine; swelling in legs and feet; fatigue; hypertension

Root Cause:
Immune-mediated damage to the glomerular capillaries, often associated with immune complex deposition or complement dysregulation.

How it's Diagnosed: videos
Diagnosed through kidney biopsy showing mesangial and capillary changes.

Treatment:
Treated with corticosteroids, immunosuppressants, or treatment of underlying causes (e.g., infections).

Medications:
Corticosteroids, immunosuppressants (e.g., mycophenolate mofetil, rituximab ), and antiplatelet agents in some cases.

Prevalence: How common the health condition is within a specific population.
Rare; incidence is approximately 1 case per million annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic infections (e.g., hepatitis C), autoimmune diseases, and complement dysregulation disorders.

Prognosis: The expected outcome or course of the condition over time.
Progressive; outcomes depend on the severity and response to treatment. May lead to chronic kidney disease or end-stage renal disease.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease, hypertension, and increased risk of cardiovascular events.