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Sub-Category:

Rapidly Progressive Glomerulonephritis (RPGN)

Number of Conditions: 1

Crescentic Glomerulonephritis

Specialty: Nephrology

Category: Glomerular Diseases

Sub-category: Rapidly Progressive Glomerulonephritis (RPGN)

Symptoms:
hematuria; proteinuria; rapidly worsening kidney function; edema; fatigue; hypertension

Root Cause:
Severe glomerular inflammation with crescent formation on biopsy, often due to autoimmune diseases (e.g., Goodpasture syndrome, ANCA-associated vasculitis).

How it's Diagnosed: videos
Urinalysis (proteinuria, hematuria), kidney biopsy (crescent formation in glomeruli), serologic tests (e.g., ANCA, anti-GBM antibodies).

Treatment:
Aggressive immunosuppressive therapy and plasmapheresis; dialysis in severe cases.

Medications:
High-dose corticosteroids (e.g., methylprednisolone ), cyclophosphamide , rituximab , and plasmapheresis to remove pathogenic antibodies.

Prevalence: How common the health condition is within a specific population.
Rare but life-threatening; most common in older adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Autoimmune diseases, infections, certain medications, genetic predisposition.

Prognosis: The expected outcome or course of the condition over time.
Poor without prompt treatment; variable outcomes with therapy, ranging from partial recovery to chronic kidney disease.

Complications: Additional problems or conditions that may arise as a result of the original condition.
End-stage renal disease, recurrence of disease, severe hypertension.